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IVM & Parasites
Ivermectin mass drug administration to humans or livestock is a potential vector control tool for malaria elimination. The mosquito-lethal effect of ivermectin in clinical trials exceeds that predicted from in vitro laboratory experiments, suggesting that ivermectin metabolites have mosquito-lethal effect. The three primary ivermectin metabolites in humans (i.e., M1 (3″-O-demethyl ivermectin), M3 (4-hydroxymethyl ivermectin), and…
Bacteria & Leukemia
The spread of bacteria leads to the release of inflammatory molecules in the blood, which in turn promote the proliferation of hematopoietic stem cells that lack TET2 expression. This sets the stage for pre-leukemic myeloproliferation. https://www.uchicagomedicine.org/forefront/cancer-articles/bacterial-signals-set-the-stage-for-leukemia#:~:text=The%20spread%20of%20bacteria%20leads,stage%20for%20pre-leukemic%20myeloproliferation
Berberine & cardiovascular, gastrointestinal, and endocrine diseases
The gastrointestinal microbiota is a multi-faceted system that is unraveling novel contributors to the development and progression of several diseases. Berberine has been used to treat obesity, diabetes mellitus, atherosclerosis, and metabolic diseases in China. There are also clinical trials regarding berberine use in cardiovascular, gastrointestinal, and endocrine diseases. Berberine elicits clinical benefits at standard…
Ketogenic Diet and Epilepsy: What We Know So Far
Authors: Isabella D’Andrea Meira, et al. Journal: Frontiers in Neuroscience (January 29, 2019) Link: PMC Full Text Key Takeaways from the 2019 Review: 1. Effectiveness The ketogenic diet (KD) is a well-established, non-pharmacological treatment for drug-resistant (refractory) epilepsy. In children: Studies showed >50% seizure reduction in a significant percentage of patients, with some achieving seizure…
Covid Response at Five Years: Voting
It is now clear that the overhaul of our election system was a deliberate initiative from the outset of the pandemic response. In March 2020, when the government’s official policy was still “Two weeks to flatten the curve,” the administrative state began instituting the infrastructure to hijack the November presidential election, more than 30 weeks…
Ivermectin & Cancer
Ivermectin induces cell cycle arrest and caspase-dependent apoptosis in human urothelial carcinoma cells https://www.medsci.org/v19p1567.htm
