Emerging research suggests that lower insulin levels and reduced insulin signaling may be associated with increased lifespan. Studies in animal models, as well as observational data in humans, indicate that chronically elevated insulin — often linked to high-carbohydrate diets, insulin resistance, and metabolic dysfunction — may accelerate aging processes. Conversely, improved insulin sensitivity and lower circulating insulin levels appear to correlate with enhanced metabolic health and longevity markers.
The research explores mechanisms such as reduced oxidative stress, improved mitochondrial function, and decreased activation of growth pathways like mTOR, all of which are associated with slower biological aging. While the findings are promising, they underscore the importance of metabolic health rather than extreme dietary restriction. Maintaining healthy insulin dynamics through nutrition, physical activity, and body composition may play a key role in long-term health and lifespan
>> Longer insulin is low, longer life span. https://pubmed.ncbi.nlm.nih.gov/21070591/