Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing
Consistently, ivermectin induces higher levels of oxidative stress and damage in CML than normal counterparts. Antioxidant NAC rescues ivermectin’s effects, confirming oxidative stress as the mechanism of its action in CML. Our work provides the fundamental evidence to repurpose ivermectin for CML treatment. Our work also highlights the therapeutic value of targeting mitochondria respiration in CML.
https://pubmed.ncbi.nlm.nih.gov/29428725/
