Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications
Key points In a longitudinal study that followed individuals seronegative for Epstein–Barr virus (EBV) over time, multiple sclerosis (MS) risk increased more than 30-fold after EBV infection. The results are unlikely to be explained by reverse causation or confounding factors. Among individuals who are EBV positive, those with a history of infectious mononucleosis or with…